Drug interactions
Metronidazole + Pemigatinib
Severity: Moderate
Metronidazole and Pemigatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is a CYP3A4 substrate, and inhibitors raise its exposure and the risk of hyperphosphatemia and ocular toxicity. Metronidazole is a weak inhibitor, so a clinically important rise is uncertain.
What this interaction means in plain words
Metronidazole and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Pemigatinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing pemigatinib metabolism.
What to do
Monitor serum phosphate and visual symptoms. Reduce the pemigatinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Pemigatinib
Frequently asked questions
Can I take Metronidazole with Pemigatinib?
MediHelp rates the interaction as moderate. Metronidazole and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemigatinib is a CYP3A4 substrate, and inhibitors raise its exposure and the risk of hyperphosphatemia and ocular toxicity. Metronidazole is a weak inhibitor, so a clinically important rise is uncertain.
How serious is the interaction between Metronidazole and Pemigatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum phosphate and visual symptoms. Reduce the pemigatinib dose if toxicity develops.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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