Drug interactions
Metronidazole + Pexidartinib
Severity: Moderate
Metronidazole and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is metabolized by CYP3A4 and carries a risk of serious liver injury. Higher exposure from CYP3A4 inhibition could increase hepatotoxicity, although metronidazole is only a weak inhibitor.
What this interaction means in plain words
Metronidazole and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Pexidartinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing pexidartinib clearance.
What to do
Monitor liver tests more often during co-treatment. Reduce the pexidartinib dose or stop it if liver enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Metronidazole with Pexidartinib?
MediHelp rates the interaction as moderate. Metronidazole and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is metabolized by CYP3A4 and carries a risk of serious liver injury. Higher exposure from CYP3A4 inhibition could increase hepatotoxicity, although metronidazole is only a weak inhibitor.
How serious is the interaction between Metronidazole and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests more often during co-treatment. Reduce the pexidartinib dose or stop it if liver enzymes rise.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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