Drug interactions
Metronidazole + Quetiapine
Severity: Minor
Metronidazole and Quetiapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is cleared mainly by CYP3A4, so inhibition can raise levels and increase sedation, orthostatic hypotension and QT effects. Metronidazole is a weak inhibitor, though it has rare QT-prolonging effects of its own.
What this interaction means in plain words
Metronidazole and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Quetiapine belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole, with minor additive QT effects.
What to do
No dose change is usually needed; monitor for excess sedation and hypotension, and check ECG if other QT-prolonging drugs are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Metronidazole with Quetiapine?
MediHelp rates the interaction as minor. Metronidazole and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quetiapine is cleared mainly by CYP3A4, so inhibition can raise levels and increase sedation, orthostatic hypotension and QT effects. Metronidazole is a weak inhibitor, though it has rare QT-prolonging effects of its own.
How serious is the interaction between Metronidazole and Quetiapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for excess sedation and hypotension, and check ECG if other QT-prolonging drugs are used.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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