Drug interactions
Metronidazole + Sufentanil
Severity: Minor
Metronidazole and Sufentanil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared by CYP3A4, and potent inhibitors can prolong its respiratory depressant effects. Metronidazole is a weak inhibitor at most, so the effect is expected to be small.
What this interaction means in plain words
Metronidazole and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Sufentanil belongs to Musculoskeletal.
Why it happens
Possible weak inhibition of CYP3A4-mediated sufentanil metabolism.
What to do
Titrate sufentanil to effect and monitor respiratory rate and sedation as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Metronidazole with Sufentanil?
MediHelp rates the interaction as minor. Metronidazole and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sufentanil is cleared by CYP3A4, and potent inhibitors can prolong its respiratory depressant effects. Metronidazole is a weak inhibitor at most, so the effect is expected to be small.
How serious is the interaction between Metronidazole and Sufentanil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to effect and monitor respiratory rate and sedation as usual.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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