Drug interactions
Metronidazole + Tinidazole
Severity: Moderate
Metronidazole and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are nitroimidazole antimicrobials with overlapping spectra and similar adverse effects, so combining them offers no therapeutic benefit and adds duplicate toxicity such as nausea, metallic taste and neurotoxicity. There is no meaningful pharmacokinetic interaction.
What this interaction means in plain words
Metronidazole and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Tinidazole belongs to Anti Parasitic.
Why it happens
Therapeutic duplication with additive nitroimidazole adverse effects, including neurotoxicity and disulfiram-like reactions.
What to do
Avoid using both together and choose a single nitroimidazole for the indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Metronidazole with Tinidazole?
MediHelp rates the interaction as moderate. Metronidazole and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are nitroimidazole antimicrobials with overlapping spectra and similar adverse effects, so combining them offers no therapeutic benefit and adds duplicate toxicity such as nausea, metallic taste and neurotoxicity. There is no meaningful pharmacokinetic interaction.
How serious is the interaction between Metronidazole and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together and choose a single nitroimidazole for the indication.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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