Drug interactions
Metronidazole + Vardenafil
Severity: Minor
Metronidazole and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is not a clinically significant CYP3A4 inhibitor, so an important change in vardenafil exposure is unlikely.
What this interaction means in plain words
Metronidazole and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Vardenafil belongs to Genitourinary.
Why it happens
No well-established mechanism; weak or theoretical effect on metabolism.
What to do
No dose adjustment needed; monitor routinely for tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Vardenafil?
MediHelp rates the interaction as minor. Metronidazole and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is not a clinically significant CYP3A4 inhibitor, so an important change in vardenafil exposure is unlikely.
How serious is the interaction between Metronidazole and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; monitor routinely for tolerability.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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