Drug interactions
Metronidazole + Verapamil
Severity: Minor
Metronidazole and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a CYP3A4 substrate, and higher levels may cause bradycardia, AV block and hypotension. Metronidazole is a weak inhibitor, so a clinically significant rise is unlikely.
What this interaction means in plain words
Metronidazole and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Verapamil belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing verapamil metabolism.
What to do
No routine adjustment is needed; monitor heart rate and blood pressure when therapy is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Metronidazole with Verapamil?
MediHelp rates the interaction as minor. Metronidazole and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil is a CYP3A4 substrate, and higher levels may cause bradycardia, AV block and hypotension. Metronidazole is a weak inhibitor, so a clinically significant rise is unlikely.
How serious is the interaction between Metronidazole and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor heart rate and blood pressure when therapy is started.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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