Drug interactions
Metronidazole + Voclosporin
Severity: Minor
Metronidazole and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a CYP3A4 substrate with a narrow therapeutic window, and moderate or strong CYP3A4 inhibitors raise its exposure. Metronidazole has at most weak CYP3A4 inhibitory activity, so a clinically meaningful rise is unlikely but cannot be fully excluded. Higher voclosporin levels could worsen nephrotoxicity, hypertension and hyperkalemia.
What this interaction means in plain words
Metronidazole and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Voclosporin belongs to Miscellaneous.
Why it happens
Possible weak inhibition of CYP3A4-mediated voclosporin metabolism.
What to do
No empirical dose reduction is needed; monitor eGFR, blood pressure and potassium when starting or stopping metronidazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metronidazole and Voclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Metronidazole with Voclosporin?
MediHelp rates the interaction as minor. Metronidazole and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin is a CYP3A4 substrate with a narrow therapeutic window, and moderate or strong CYP3A4 inhibitors raise its exposure. Metronidazole has at most weak CYP3A4 inhibitory activity, so a clinically meaningful rise is unlikely but cannot be fully excluded. Higher voclosporin levels could worsen nephrotoxicity, hypertension and hyperkalemia.
How serious is the interaction between Metronidazole and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose reduction is needed; monitor eGFR, blood pressure and potassium when starting or stopping metronidazole.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
