Drug interactions
metronidazole + warfarin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ INR/bleeding risk.
Mechanism of action
CYP2C9 inhibition.
Clinical management
Avoid or adjust warfarin; monitor INR.
Drug reference
References
Frequently asked questions
Can I take metronidazole with warfarin?
The interaction is rated: Major. ↑ INR/bleeding risk.
How serious is the interaction between metronidazole and warfarin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between metronidazole and warfarin managed?
Avoid or adjust warfarin; monitor INR.
Why do metronidazole and warfarin interact?
CYP2C9 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.