Drug interactions
Metyrapone + Triamcinolone acetonide injectable
Severity: Moderate
Metyrapone and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamcinolone is a systemic glucocorticoid that suppresses ACTH, so it opposes metyrapone's effect on the pituitary-adrenal axis and invalidates diagnostic testing. It also suppresses endogenous cortisol, confounding monitoring.
What this interaction means in plain words
Metyrapone and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Exogenous glucocorticoid activity with negative feedback on ACTH opposes metyrapone's inhibition of cortisol synthesis and the expected compensatory ACTH rise.
What to do
Avoid corticosteroids before and during diagnostic metyrapone testing; allow adequate washout of depot triamcinolone. In block-and-replace therapy, give deliberate replacement with cortisol monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
Frequently asked questions
Can I take Metyrapone with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Metyrapone and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamcinolone is a systemic glucocorticoid that suppresses ACTH, so it opposes metyrapone's effect on the pituitary-adrenal axis and invalidates diagnostic testing. It also suppresses endogenous cortisol, confounding monitoring.
How serious is the interaction between Metyrapone and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid corticosteroids before and during diagnostic metyrapone testing; allow adequate washout of depot triamcinolone. In block-and-replace therapy, give deliberate replacement with cortisol monitoring.
What other medicines interact with Metyrapone?
MediHelp also lists interactions of Metyrapone with, for example, Pacritinib, Budesonide, Cortisone. The full list is on the Metyrapone page.
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