Drug interactions
Mexiletine + Quinacrine
Severity: Moderate
Mexiletine and Quinacrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6 and could raise mexiletine levels. Both drugs can have cardiac and CNS effects, so toxicity is a concern.
What this interaction means in plain words
Mexiletine and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP2D6 inhibition reduces mexiletine clearance.
What to do
Monitor ECG and for mexiletine toxicity signs such as tremor and dizziness. Consider reducing the mexiletine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Mexiletine with Quinacrine?
MediHelp rates the interaction as moderate. Mexiletine and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinacrine may inhibit CYP2D6 and could raise mexiletine levels. Both drugs can have cardiac and CNS effects, so toxicity is a concern.
How serious is the interaction between Mexiletine and Quinacrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for mexiletine toxicity signs such as tremor and dizziness. Consider reducing the mexiletine dose.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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