Drug interactions
Mexiletine + Somatropin
Severity: Minor
Mexiletine and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin may increase CYP-mediated clearance, which could modestly lower concentrations of mexiletine. Data are limited and the effect is probably small.
What this interaction means in plain words
Mexiletine and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mexiletine belongs to Cardiovascular; Somatropin belongs to Endocrine.
Why it happens
Somatropin may induce CYP-mediated metabolism, including CYP1A2.
What to do
Monitor clinical response to mexiletine when somatropin is started or the dose changed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Mexiletine with Somatropin?
MediHelp rates the interaction as minor. Mexiletine and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Somatropin may increase CYP-mediated clearance, which could modestly lower concentrations of mexiletine. Data are limited and the effect is probably small.
How serious is the interaction between Mexiletine and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to mexiletine when somatropin is started or the dose changed.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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