Drug interactions
Mexiletine + Venlafaxine
Severity: Minor
Mexiletine and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is a weak CYP2D6 inhibitor and may modestly raise mexiletine levels. Venlafaxine can also cause blood pressure elevation and, rarely, QT prolongation.
What this interaction means in plain words
Mexiletine and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mexiletine belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Venlafaxine weakly inhibits CYP2D6 metabolism of mexiletine.
What to do
Monitor for mexiletine adverse effects such as tremor, dizziness and nausea. Reduce the mexiletine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Mexiletine with Venlafaxine?
MediHelp rates the interaction as minor. Mexiletine and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Venlafaxine is a weak CYP2D6 inhibitor and may modestly raise mexiletine levels. Venlafaxine can also cause blood pressure elevation and, rarely, QT prolongation.
How serious is the interaction between Mexiletine and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mexiletine adverse effects such as tremor, dizziness and nausea. Reduce the mexiletine dose if they occur.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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