Drug interactions
Miconazole vaginal + Tolazamide
Severity: Minor
Miconazole vaginal and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole is absorbed systemically to a small extent and may inhibit CYP2C9, which can raise sulfonylurea levels. Hypoglycemia has been reported with miconazole, mainly with oral gel.
What this interaction means in plain words
Miconazole vaginal and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP2C9-mediated sulfonylurea metabolism by absorbed miconazole.
What to do
Counsel the patient on hypoglycemia symptoms and check blood glucose during prolonged or repeated vaginal courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Miconazole vaginal with Tolazamide?
MediHelp rates the interaction as minor. Miconazole vaginal and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole is absorbed systemically to a small extent and may inhibit CYP2C9, which can raise sulfonylurea levels. Hypoglycemia has been reported with miconazole, mainly with oral gel.
How serious is the interaction between Miconazole vaginal and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on hypoglycemia symptoms and check blood glucose during prolonged or repeated vaginal courses.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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