Drug interactions
Miconazole vaginal + Vinblastine
Severity: Minor
Miconazole vaginal and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has limited systemic absorption, though it can inhibit CYP3A4 and some interaction has been reported with other substrates. A meaningful rise in vinblastine exposure is unlikely with short courses.
What this interaction means in plain words
Miconazole vaginal and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Absorbed miconazole may inhibit CYP3A4, slightly reducing vinblastine clearance.
What to do
Short courses can usually be given with routine monitoring of vinblastine toxicity. Consider a non-azole alternative if prolonged treatment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Miconazole vaginal with Vinblastine?
MediHelp rates the interaction as minor. Miconazole vaginal and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has limited systemic absorption, though it can inhibit CYP3A4 and some interaction has been reported with other substrates. A meaningful rise in vinblastine exposure is unlikely with short courses.
How serious is the interaction between Miconazole vaginal and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Short courses can usually be given with routine monitoring of vinblastine toxicity. Consider a non-azole alternative if prolonged treatment is needed.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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