Drug interactions
Midazolam intranasal + Ziprasidone
Severity: Moderate
Midazolam intranasal and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam causes sedation and respiratory depression, and ziprasidone adds CNS depression. Together they may deepen sedation and increase the risk of hypoventilation or apnea.
What this interaction means in plain words
Midazolam intranasal and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and antipsychotic sedation.
What to do
Use the lowest effective midazolam dose and monitor respiration, oxygen saturation and level of consciousness after dosing. Ensure the patient is observed until fully recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Midazolam intranasal with Ziprasidone?
MediHelp rates the interaction as moderate. Midazolam intranasal and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam causes sedation and respiratory depression, and ziprasidone adds CNS depression. Together they may deepen sedation and increase the risk of hypoventilation or apnea.
How serious is the interaction between Midazolam intranasal and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor respiration, oxygen saturation and level of consciousness after dosing. Ensure the patient is observed until fully recovered.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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