Drug interactions
Mifepristone + Mometasone intranasal
Severity: Minor
Mifepristone and Mometasone intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise systemic exposure to mometasone, which is cleared by this enzyme. Intranasal absorption is small, but higher exposure could add to corticosteroid effects. Mifepristone also blocks glucocorticoid receptors, which may blunt mometasone's effect.
What this interaction means in plain words
Mifepristone and Mometasone intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mifepristone inhibits CYP3A4-mediated metabolism of mometasone and antagonizes glucocorticoid receptors.
What to do
No routine adjustment is needed at standard intranasal doses. Review for systemic corticosteroid effects if therapy is prolonged or doses are high.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Mometasone intranasal?
MediHelp rates the interaction as minor. Mifepristone and Mometasone intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4 and may raise systemic exposure to mometasone, which is cleared by this enzyme. Intranasal absorption is small, but higher exposure could add to corticosteroid effects. Mifepristone also blocks glucocorticoid receptors, which may blunt mometasone's effect.
How serious is the interaction between Mifepristone and Mometasone intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed at standard intranasal doses. Review for systemic corticosteroid effects if therapy is prolonged or doses are high.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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