Drug interactions
Mifepristone + Nafcillin
Severity: Moderate
Mifepristone and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin may induce CYP3A4 and reduce mifepristone exposure, potentially weakening its therapeutic effect. The manufacturer advises against combining mifepristone with CYP3A4 inducers because they have not been studied.
What this interaction means in plain words
Mifepristone and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing mifepristone metabolism.
What to do
Use an alternative antibiotic that does not induce CYP3A4 if possible. If the combination is needed, monitor clinical response to mifepristone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Nafcillin?
MediHelp rates the interaction as moderate. Mifepristone and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin may induce CYP3A4 and reduce mifepristone exposure, potentially weakening its therapeutic effect. The manufacturer advises against combining mifepristone with CYP3A4 inducers because they have not been studied.
How serious is the interaction between Mifepristone and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic that does not induce CYP3A4 if possible. If the combination is needed, monitor clinical response to mifepristone.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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