Drug interactions
Mifepristone + Norelgestromin
Severity: Moderate
Mifepristone and Norelgestromin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is an antiprogestogen and may oppose the progestin activity of norelgestromin. This can reduce the contraceptive reliability of the transdermal patch.
What this interaction means in plain words
Mifepristone and Norelgestromin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone blocks progesterone receptors, antagonizing the progestin effect of norelgestromin.
What to do
Advise a reliable non-hormonal backup contraceptive method during mifepristone treatment and for a period after it ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Norelgestromin?
MediHelp rates the interaction as moderate. Mifepristone and Norelgestromin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone is an antiprogestogen and may oppose the progestin activity of norelgestromin. This can reduce the contraceptive reliability of the transdermal patch.
How serious is the interaction between Mifepristone and Norelgestromin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise a reliable non-hormonal backup contraceptive method during mifepristone treatment and for a period after it ends.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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