Drug interactions
Mifepristone + Octreotide
Severity: Major
Mifepristone and Octreotide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval, and octreotide can add to this through QT changes and bradycardia. The combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Mifepristone and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QTc prolongation).
What to do
Prefer an alternative if possible. If used together, obtain a baseline ECG, monitor QTc, and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Octreotide
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Octreotide?
MediHelp rates the interaction as major. Mifepristone and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval, and octreotide can add to this through QT changes and bradycardia. The combination may raise the risk of torsades de pointes.
How serious is the interaction between Mifepristone and Octreotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative if possible. If used together, obtain a baseline ECG, monitor QTc, and correct potassium and magnesium.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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