Drug interactions
Mifepristone + Olanzapine
Severity: Moderate
Mifepristone and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone prolongs the QT interval, and olanzapine has a modest QT effect, so the combination may increase the risk of arrhythmia, particularly torsades de pointes, in susceptible patients.
What this interaction means in plain words
Mifepristone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Prefer an alternative if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Olanzapine?
MediHelp rates the interaction as moderate. Mifepristone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone prolongs the QT interval, and olanzapine has a modest QT effect, so the combination may increase the risk of arrhythmia, particularly torsades de pointes, in susceptible patients.
How serious is the interaction between Mifepristone and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Prefer an alternative if the patient has other QT risk factors.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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