Drug interactions
Mifepristone + Paclitaxel protein bound
Severity: Moderate
Mifepristone and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase exposure to paclitaxel by inhibiting CYP3A4, which contributes to its metabolism along with CYP2C8. This may increase neutropenia and neuropathy.
What this interaction means in plain words
Mifepristone and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of paclitaxel by mifepristone.
What to do
Monitor blood counts and neuropathy closely. Consider an alternative to mifepristone or a paclitaxel dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Mifepristone and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may increase exposure to paclitaxel by inhibiting CYP3A4, which contributes to its metabolism along with CYP2C8. This may increase neutropenia and neuropathy.
How serious is the interaction between Mifepristone and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy closely. Consider an alternative to mifepristone or a paclitaxel dose reduction if toxicity develops.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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