Drug interactions
Mifepristone + Procainamide
Severity: Major
Mifepristone and Procainamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide prolongs the QT interval and mifepristone has QT-prolonging potential. Together they may raise the risk of torsades de pointes, particularly in patients with structural heart disease or electrolyte abnormalities.
What this interaction means in plain words
Mifepristone and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation through pharmacodynamic synergism.
What to do
Avoid the combination when an alternative exists; if used, monitor ECG for QTc and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Procainamide?
MediHelp rates the interaction as major. Mifepristone and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procainamide prolongs the QT interval and mifepristone has QT-prolonging potential. Together they may raise the risk of torsades de pointes, particularly in patients with structural heart disease or electrolyte abnormalities.
How serious is the interaction between Mifepristone and Procainamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when an alternative exists; if used, monitor ECG for QTc and keep potassium and magnesium within normal range.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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