Drug interactions
Mifepristone + Protriptyline
Severity: Moderate
Mifepristone and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so concurrent use may increase the risk of ventricular arrhythmias including torsades de pointes. Tricyclic antidepressants add further risk at higher exposures or with cardiac disease.
What this interaction means in plain words
Mifepristone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation; mifepristone may also inhibit CYP2D6 and raise protriptyline levels.
What to do
Prefer an alternative antidepressant when feasible; otherwise obtain an ECG and monitor QTc and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Protriptyline?
MediHelp rates the interaction as moderate. Mifepristone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, so concurrent use may increase the risk of ventricular arrhythmias including torsades de pointes. Tricyclic antidepressants add further risk at higher exposures or with cardiac disease.
How serious is the interaction between Mifepristone and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antidepressant when feasible; otherwise obtain an ECG and monitor QTc and electrolytes.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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