Drug interactions
Mifepristone + Rabeprazole
Severity: Minor
Mifepristone and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, which has a minor role in rabeprazole metabolism. Rabeprazole exposure may rise somewhat, but it has a wide safety margin and clinical impact is likely small.
What this interaction means in plain words
Mifepristone and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Mifepristone inhibits CYP3A4, reducing a minor metabolic pathway of rabeprazole.
What to do
No dose adjustment is normally needed; monitor for PPI adverse effects such as headache or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Rabeprazole?
MediHelp rates the interaction as minor. Mifepristone and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4, which has a minor role in rabeprazole metabolism. Rabeprazole exposure may rise somewhat, but it has a wide safety margin and clinical impact is likely small.
How serious is the interaction between Mifepristone and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed; monitor for PPI adverse effects such as headache or gastrointestinal upset.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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