Drug interactions
Mifepristone + Sacubitril / valsartan
Severity: Minor
Mifepristone and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may inhibit hepatic uptake transporters such as OATP1B1, potentially raising valsartan exposure. Mifepristone can also cause hypokalemia, and the combination may affect blood pressure and renal function. The clinical effect is likely modest.
What this interaction means in plain words
Mifepristone and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible OATP1B1 inhibition by mifepristone increasing valsartan exposure; not firmly established.
What to do
Monitor blood pressure, renal function and potassium during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Mifepristone and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone may inhibit hepatic uptake transporters such as OATP1B1, potentially raising valsartan exposure. Mifepristone can also cause hypokalemia, and the combination may affect blood pressure and renal function. The clinical effect is likely modest.
How serious is the interaction between Mifepristone and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium during combined therapy.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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