Drug interactions
Mifepristone + Saquinavir
Severity: Contraindicated
Mifepristone and Saquinavir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit CYP3A4 and prolong the QT interval. Saquinavir is a CYP3A4 substrate, and combined use risks higher saquinavir exposure and additive QT prolongation with arrhythmia risk.
What this interaction means in plain words
Mifepristone and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Mutual CYP3A4 inhibition with additive QT prolongation.
What to do
Do not combine; choose an antiretroviral or alternative with less QT risk. If exposure is unavoidable, perform ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Saquinavir?
MediHelp rates the interaction as contraindicated. Mifepristone and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs inhibit CYP3A4 and prolong the QT interval. Saquinavir is a CYP3A4 substrate, and combined use risks higher saquinavir exposure and additive QT prolongation with arrhythmia risk.
How serious is the interaction between Mifepristone and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antiretroviral or alternative with less QT risk. If exposure is unavoidable, perform ECG monitoring and correct electrolytes.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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