Drug interactions
Mifepristone + Segesterone / ethinyl estradiol
Severity: Moderate
Mifepristone and Segesterone / ethinyl estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone antagonizes progesterone receptors and may counteract the progestin activity of segesterone in the contraceptive vaginal ring. This may reduce contraceptive efficacy.
What this interaction means in plain words
Mifepristone and Segesterone / ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone blocks progesterone receptors, opposing the progestogenic effect of segesterone.
What to do
Use a non-hormonal backup contraceptive method during mifepristone therapy and for a period after stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Segesterone / ethinyl estradiol?
MediHelp rates the interaction as moderate. Mifepristone and Segesterone / ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone antagonizes progesterone receptors and may counteract the progestin activity of segesterone in the contraceptive vaginal ring. This may reduce contraceptive efficacy.
How serious is the interaction between Mifepristone and Segesterone / ethinyl estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal backup contraceptive method during mifepristone therapy and for a period after stopping.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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