Drug interactions
Mifepristone + Selumetinib
Severity: Major
Mifepristone and Selumetinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib is cleared largely by CYP3A4, and mifepristone is a strong inhibitor of this enzyme. Higher selumetinib exposure can increase gastrointestinal toxicity, rash, cardiomyopathy and ocular toxicity.
What this interaction means in plain words
Mifepristone and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Selumetinib belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4-mediated metabolism of selumetinib.
What to do
Avoid if possible; if unavoidable, reduce the selumetinib dose as specified in its labeling for strong CYP3A4 inhibitors and monitor for adverse effects. Restore the prior dose after the inhibitor has been cleared.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Mifepristone with Selumetinib?
MediHelp rates the interaction as major. Mifepristone and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selumetinib is cleared largely by CYP3A4, and mifepristone is a strong inhibitor of this enzyme. Higher selumetinib exposure can increase gastrointestinal toxicity, rash, cardiomyopathy and ocular toxicity.
How serious is the interaction between Mifepristone and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, reduce the selumetinib dose as specified in its labeling for strong CYP3A4 inhibitors and monitor for adverse effects. Restore the prior dose after the inhibitor has been cleared.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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