Drug interactions
Mifepristone + Sofosbuvir / velpatasvir
Severity: Minor
Mifepristone and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise velpatasvir concentrations through inhibition of CYP3A4 and possibly P-gp. The clinical effect is generally modest because velpatasvir is metabolized by several pathways.
What this interaction means in plain words
Mifepristone and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mifepristone inhibits CYP3A4 (and possibly intestinal P-gp), reducing the clearance of velpatasvir.
What to do
No routine dose change is needed; monitor for velpatasvir adverse effects such as headache and fatigue during prolonged co-use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Mifepristone and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone may raise velpatasvir concentrations through inhibition of CYP3A4 and possibly P-gp. The clinical effect is generally modest because velpatasvir is metabolized by several pathways.
How serious is the interaction between Mifepristone and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for velpatasvir adverse effects such as headache and fatigue during prolonged co-use.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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