Drug interactions
Mifepristone + Tezacaftor
Severity: Moderate
Mifepristone and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tezacaftor is a CYP3A4 substrate and mifepristone strongly inhibits this enzyme. Exposure to tezacaftor may increase, raising the likelihood of adverse effects such as liver enzyme elevation.
What this interaction means in plain words
Mifepristone and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone inhibits CYP3A4, reducing tezacaftor clearance.
What to do
If used with a strong CYP3A inhibitor, follow the reduced-dose tezacaftor/ivacaftor schedule in the labeling and monitor liver function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Tezacaftor?
MediHelp rates the interaction as moderate. Mifepristone and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tezacaftor is a CYP3A4 substrate and mifepristone strongly inhibits this enzyme. Exposure to tezacaftor may increase, raising the likelihood of adverse effects such as liver enzyme elevation.
How serious is the interaction between Mifepristone and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used with a strong CYP3A inhibitor, follow the reduced-dose tezacaftor/ivacaftor schedule in the labeling and monitor liver function.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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