Drug interactions
Mifepristone + Tiagabine
Severity: Moderate
Mifepristone and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tiagabine is extensively metabolized by CYP3A4, so inhibition may raise its concentrations. This can lead to dizziness, somnolence, confusion and in some cases seizures.
What this interaction means in plain words
Mifepristone and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone inhibits CYP3A4-mediated tiagabine metabolism.
What to do
Monitor for CNS adverse effects and seizure control, and lower the tiagabine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Tiagabine?
MediHelp rates the interaction as moderate. Mifepristone and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tiagabine is extensively metabolized by CYP3A4, so inhibition may raise its concentrations. This can lead to dizziness, somnolence, confusion and in some cases seizures.
How serious is the interaction between Mifepristone and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and seizure control, and lower the tiagabine dose if toxicity appears.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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