Drug interactions
Mifepristone + Tofacitinib
Severity: Moderate
Mifepristone and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase tofacitinib exposure, with potentially greater immunosuppression and risk of infection, cytopenias or lipid changes. The effect is relevant mainly with chronic mifepristone dosing rather than single doses.
What this interaction means in plain words
Mifepristone and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Tofacitinib belongs to Musculoskeletal.
Why it happens
CYP3A4 inhibition by mifepristone decreases tofacitinib clearance.
What to do
With chronic mifepristone use, reduce the tofacitinib dose per labeling for CYP3A4 inhibitors, for example halving the daily exposure. Monitor for infection and blood count changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mifepristone and Tofacitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Tofacitinib?
MediHelp rates the interaction as moderate. Mifepristone and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase tofacitinib exposure, with potentially greater immunosuppression and risk of infection, cytopenias or lipid changes. The effect is relevant mainly with chronic mifepristone dosing rather than single doses.
How serious is the interaction between Mifepristone and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With chronic mifepristone use, reduce the tofacitinib dose per labeling for CYP3A4 inhibitors, for example halving the daily exposure. Monitor for infection and blood count changes.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
