Drug interactions
Mifepristone + Triamcinolone acetonide injectable
Severity: Major
Mifepristone and Triamcinolone acetonide injectable: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone blocks glucocorticoid receptors and may reduce the effect of corticosteroids, and its labeling for pregnancy termination lists long-term corticosteroid therapy as a contraindication. Reduced steroid effect can cause adrenal insufficiency symptoms or loss of disease control.
What this interaction means in plain words
Mifepristone and Triamcinolone acetonide injectable can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mifepristone antagonizes the glucocorticoid receptor, opposing the effect of triamcinolone.
What to do
Avoid mifepristone in patients on long-term corticosteroids. If it is used, monitor for adrenal insufficiency and consider higher steroid doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Triamcinolone acetonide injectable?
MediHelp rates the interaction as major. Mifepristone and Triamcinolone acetonide injectable can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone blocks glucocorticoid receptors and may reduce the effect of corticosteroids, and its labeling for pregnancy termination lists long-term corticosteroid therapy as a contraindication. Reduced steroid effect can cause adrenal insufficiency symptoms or loss of disease control.
How serious is the interaction between Mifepristone and Triamcinolone acetonide injectable?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid mifepristone in patients on long-term corticosteroids. If it is used, monitor for adrenal insufficiency and consider higher steroid doses.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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