Drug interactions
Mifepristone + Triazolam
Severity: Major
Mifepristone and Triazolam: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a sensitive CYP3A4 substrate and mifepristone inhibits CYP3A4. Higher triazolam levels can produce profound sedation, amnesia and respiratory depression.
What this interaction means in plain words
Mifepristone and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of triazolam.
What to do
Avoid combination during chronic mifepristone therapy and use a hypnotic not dependent on CYP3A4 such as temazepam. If used, give a markedly reduced triazolam dose and monitor sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Triazolam?
MediHelp rates the interaction as major. Mifepristone and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triazolam is a sensitive CYP3A4 substrate and mifepristone inhibits CYP3A4. Higher triazolam levels can produce profound sedation, amnesia and respiratory depression.
How serious is the interaction between Mifepristone and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination during chronic mifepristone therapy and use a hypnotic not dependent on CYP3A4 such as temazepam. If used, give a markedly reduced triazolam dose and monitor sedation.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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