Drug interactions
Mifepristone + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Mifepristone and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta agonist, can prolong the QT interval and cause tachycardia, and mifepristone also prolongs QT. Vilanterol is a CYP3A4 substrate, and inhibition may increase its systemic exposure.
What this interaction means in plain words
Mifepristone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition raising vilanterol exposure.
What to do
Monitor for palpitations and ECG changes, particularly with other QT-prolonging drugs or electrolyte disturbances, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Mifepristone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta agonist, can prolong the QT interval and cause tachycardia, and mifepristone also prolongs QT. Vilanterol is a CYP3A4 substrate, and inhibition may increase its systemic exposure.
How serious is the interaction between Mifepristone and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and ECG changes, particularly with other QT-prolonging drugs or electrolyte disturbances, and use the lowest effective doses.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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