Drug interactions
Mifepristone + Venlafaxine
Severity: Minor
Mifepristone and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise venlafaxine concentrations, a minor pathway for the drug. The effect is likely modest because venlafaxine is mainly cleared by CYP2D6, though higher chronic mifepristone doses carry greater potential. Increased adverse effects such as nausea, hypertension and serotonergic symptoms are possible.
What this interaction means in plain words
Mifepristone and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Venlafaxine belongs to Central Nervous System.
Why it happens
Mifepristone inhibition of CYP3A4-mediated venlafaxine metabolism.
What to do
Monitor blood pressure and tolerability, and reduce the venlafaxine dose if adverse effects appear. No empiric adjustment is needed for short-course mifepristone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Venlafaxine?
MediHelp rates the interaction as minor. Mifepristone and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4 and may raise venlafaxine concentrations, a minor pathway for the drug. The effect is likely modest because venlafaxine is mainly cleared by CYP2D6, though higher chronic mifepristone doses carry greater potential. Increased adverse effects such as nausea, hypertension and serotonergic symptoms are possible.
How serious is the interaction between Mifepristone and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and reduce the venlafaxine dose if adverse effects appear. No empiric adjustment is needed for short-course mifepristone.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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