Drug interactions
Mifepristone + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Mifepristone and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, which metabolizes both vilanterol and fluticasone furoate, so systemic exposure to each may rise. This can cause cardiovascular stimulation and QT effects from vilanterol, and corticosteroid systemic effects from fluticasone.
What this interaction means in plain words
Mifepristone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition increasing exposure of both components, with additive QT prolongation potential.
What to do
Monitor for tachycardia, QT changes, hypokalemia and signs of corticosteroid excess; consider an alternative inhaler if prolonged co-use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Mifepristone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4, which metabolizes both vilanterol and fluticasone furoate, so systemic exposure to each may rise. This can cause cardiovascular stimulation and QT effects from vilanterol, and corticosteroid systemic effects from fluticasone.
How serious is the interaction between Mifepristone and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, QT changes, hypokalemia and signs of corticosteroid excess; consider an alternative inhaler if prolonged co-use is needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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