Drug interactions
Mifepristone + Vincristine liposomal
Severity: Major
Mifepristone and Vincristine liposomal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is a CYP3A4 substrate, and mifepristone may increase its exposure. This raises the risk of vincristine neurotoxicity, including peripheral neuropathy, constipation and ileus.
What this interaction means in plain words
Mifepristone and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mifepristone inhibits CYP3A4 and may also inhibit P-gp, reducing vincristine clearance.
What to do
Avoid co-administration where possible. If it is needed, monitor closely for neurotoxicity and gastrointestinal dysfunction and reduce the vincristine dose as appropriate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Vincristine liposomal?
MediHelp rates the interaction as major. Mifepristone and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vincristine is a CYP3A4 substrate, and mifepristone may increase its exposure. This raises the risk of vincristine neurotoxicity, including peripheral neuropathy, constipation and ileus.
How serious is the interaction between Mifepristone and Vincristine liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration where possible. If it is needed, monitor closely for neurotoxicity and gastrointestinal dysfunction and reduce the vincristine dose as appropriate.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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