Drug interactions
Mifepristone + Zolpidem
Severity: Moderate
Mifepristone and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise zolpidem levels, increasing sedation and the risk of next-day impairment. Effects may be more pronounced with chronic mifepristone use.
What this interaction means in plain words
Mifepristone and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Zolpidem belongs to Central Nervous System.
Why it happens
Mifepristone inhibits CYP3A4, reducing the clearance of zolpidem.
What to do
Consider a lower zolpidem starting dose and monitor for excessive sedation and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Zolpidem?
MediHelp rates the interaction as moderate. Mifepristone and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise zolpidem levels, increasing sedation and the risk of next-day impairment. Effects may be more pronounced with chronic mifepristone use.
How serious is the interaction between Mifepristone and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower zolpidem starting dose and monitor for excessive sedation and confusion.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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