Drug interactions
Milnacipran + Salsalate
Severity: Moderate
Milnacipran and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate NSAID with GI toxicity potential, and milnacipran impairs platelet serotonin uptake. Together they may increase the likelihood of bleeding.
What this interaction means in plain words
Milnacipran and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on platelet function plus NSAID-related mucosal injury.
What to do
Monitor for signs of GI bleeding and use the lowest effective salsalate dose. Add gastroprotection if other bleeding risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Milnacipran with Salsalate?
MediHelp rates the interaction as moderate. Milnacipran and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a non-acetylated salicylate NSAID with GI toxicity potential, and milnacipran impairs platelet serotonin uptake. Together they may increase the likelihood of bleeding.
How serious is the interaction between Milnacipran and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and use the lowest effective salsalate dose. Add gastroprotection if other bleeding risk factors are present.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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