Drug interactions
Milnacipran + Selegiline transdermal
Severity: Contraindicated
Milnacipran and Selegiline transdermal: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B systemically. Combining it with milnacipran carries a risk of serious serotonin syndrome and hypertensive crisis.
What this interaction means in plain words
Milnacipran and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Irreversible MAO inhibition raises monoamines while milnacipran blocks their reuptake.
What to do
Do not use together. Leave at least 2 weeks between stopping selegiline and starting milnacipran, and at least 5 days after stopping milnacipran before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Milnacipran with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Milnacipran and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B systemically. Combining it with milnacipran carries a risk of serious serotonin syndrome and hypertensive crisis.
How serious is the interaction between Milnacipran and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Leave at least 2 weeks between stopping selegiline and starting milnacipran, and at least 5 days after stopping milnacipran before starting selegiline.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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