Drug interactions
Milnacipran + Valerian
Severity: Minor
Milnacipran and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties that may add to CNS effects of milnacipran such as dizziness or somnolence. The clinical effect is generally mild.
What this interaction means in plain words
Milnacipran and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depressant effects via GABAergic activity of valerian; evidence is limited.
What to do
Advise patients to watch for excess drowsiness and avoid driving if impaired. Reduce or stop valerian if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Milnacipran with Valerian?
MediHelp rates the interaction as minor. Milnacipran and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian has sedative properties that may add to CNS effects of milnacipran such as dizziness or somnolence. The clinical effect is generally mild.
How serious is the interaction between Milnacipran and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excess drowsiness and avoid driving if impaired. Reduce or stop valerian if sedation is troublesome.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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