Drug interactions
Minoxidil + Tadalafil
Severity: Moderate
Minoxidil and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Minoxidil is a potent direct vasodilator and tadalafil adds further vasodilation. The combination can cause significant hypotension and reflex tachycardia.
What this interaction means in plain words
Minoxidil and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Minoxidil belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and potassium channel opening by minoxidil.
What to do
Start tadalafil at the lowest dose and monitor blood pressure and heart rate. Advise patients to report dizziness, syncope or chest pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Minoxidil
Frequently asked questions
Can I take Minoxidil with Tadalafil?
MediHelp rates the interaction as moderate. Minoxidil and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Minoxidil is a potent direct vasodilator and tadalafil adds further vasodilation. The combination can cause significant hypotension and reflex tachycardia.
How serious is the interaction between Minoxidil and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at the lowest dose and monitor blood pressure and heart rate. Advise patients to report dizziness, syncope or chest pain.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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