Drug interactions
Mipomersen + Rosuvastatin
Severity: Moderate
Mipomersen and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause liver enzyme elevations, and mipomersen is associated with hepatotoxicity and hepatic steatosis. Combined use may add to hepatic burden.
What this interaction means in plain words
Mipomersen and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential; no pharmacokinetic interaction is established.
What to do
Monitor ALT, AST and bilirubin per mipomersen labeling and stop therapy if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Mipomersen with Rosuvastatin?
MediHelp rates the interaction as moderate. Mipomersen and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause liver enzyme elevations, and mipomersen is associated with hepatotoxicity and hepatic steatosis. Combined use may add to hepatic burden.
How serious is the interaction between Mipomersen and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin per mipomersen labeling and stop therapy if significant elevations occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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