Drug interactions
Mipomersen + Sulindac
Severity: Moderate
Mipomersen and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation, and sulindac can rarely cause hepatotoxicity. Concurrent use may add to the risk of liver injury.
What this interaction means in plain words
Mipomersen and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes and bilirubin per mipomersen labeling and stop either drug if significant elevations occur. Consider an alternative analgesic if liver tests worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Mipomersen with Sulindac?
MediHelp rates the interaction as moderate. Mipomersen and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation, and sulindac can rarely cause hepatotoxicity. Concurrent use may add to the risk of liver injury.
How serious is the interaction between Mipomersen and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin per mipomersen labeling and stop either drug if significant elevations occur. Consider an alternative analgesic if liver tests worsen.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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