Drug interactions
Mipomersen + Valproic acid
Severity: Major
Mipomersen and Valproic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises transaminases and causes hepatic fat accumulation, and valproate is also hepatotoxic. Together the risk of liver injury may be greater and harder to interpret.
What this interaction means in plain words
Mipomersen and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hepatotoxicity from two agents that can each injure the liver.
What to do
Check liver enzymes and bilirubin before starting and at regular intervals. Stop or reconsider therapy if transaminases rise significantly or symptoms of liver injury develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Mipomersen with Valproic acid?
MediHelp rates the interaction as major. Mipomersen and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mipomersen commonly raises transaminases and causes hepatic fat accumulation, and valproate is also hepatotoxic. Together the risk of liver injury may be greater and harder to interpret.
How serious is the interaction between Mipomersen and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before starting and at regular intervals. Stop or reconsider therapy if transaminases rise significantly or symptoms of liver injury develop.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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