Drug interactions
Mipomersen + Verapamil
Severity: Moderate
Mipomersen and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can raise liver transaminases and cause hepatic fat accumulation, and verapamil is occasionally associated with liver enzyme elevations. Using them together could add to liver injury risk, although the clinical significance is mostly theoretical.
What this interaction means in plain words
Mipomersen and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Check ALT, AST and bilirubin before starting and at regular intervals during mipomersen therapy. Stop or reassess therapy if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Mipomersen with Verapamil?
MediHelp rates the interaction as moderate. Mipomersen and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can raise liver transaminases and cause hepatic fat accumulation, and verapamil is occasionally associated with liver enzyme elevations. Using them together could add to liver injury risk, although the clinical significance is mostly theoretical.
How serious is the interaction between Mipomersen and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ALT, AST and bilirubin before starting and at regular intervals during mipomersen therapy. Stop or reassess therapy if transaminases rise significantly.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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