Drug interactions
Mitapivat + Warfarin
Severity: Moderate
Mitapivat and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitapivat may induce CYP enzymes, including CYP2C9, which could reduce warfarin levels. This may lower INR and weaken anticoagulation.
What this interaction means in plain words
Mitapivat and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitapivat belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Possible enzyme induction by mitapivat increasing warfarin clearance.
What to do
Monitor INR more often when mitapivat is started or stopped. Adjust warfarin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Mitapivat
- Mitapivat + Praziquantel Minor
Frequently asked questions
Can I take Mitapivat with Warfarin?
MediHelp rates the interaction as moderate. Mitapivat and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitapivat may induce CYP enzymes, including CYP2C9, which could reduce warfarin levels. This may lower INR and weaken anticoagulation.
How serious is the interaction between Mitapivat and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more often when mitapivat is started or stopped. Adjust warfarin dose accordingly.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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