Drug interactions
Mitotane + Rabeprazole
Severity: Minor
Mitotane and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and could lower exposure to drugs cleared via this pathway. Rabeprazole depends mainly on non-enzymatic clearance, so the effect on acid suppression is likely modest but possible.
What this interaction means in plain words
Mitotane and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mitotane belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Mitotane induces CYP3A4, a minor pathway of rabeprazole metabolism.
What to do
Monitor symptom control and increase the PPI dose if acid suppression is inadequate. Consider an alternative if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Rabeprazole?
MediHelp rates the interaction as minor. Mitotane and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mitotane is a strong CYP3A4 inducer and could lower exposure to drugs cleared via this pathway. Rabeprazole depends mainly on non-enzymatic clearance, so the effect on acid suppression is likely modest but possible.
How serious is the interaction between Mitotane and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and increase the PPI dose if acid suppression is inadequate. Consider an alternative if control is lost.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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